GTX105038-产品快照
- 品牌:
- GTX105038
- 型号:
- GTX105038
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 微信咨询，cs10@gchane.com , QQ1653501665
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产品介绍
GTX105038
Genetex - GTX105038 - alpha Dystroglycan antibody (Each (100µl))
GTX105038
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. [provided by RefSeq] This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen alpha Dystroglycan Host Rabbit Reactivity Human Isotype IgG Molecular Weight 98 kDa Unit Each (100µl) Application Note Suggested starting dilutions are as follows: WB: 1:500-1:3000, ICC/IF: 1:100-1:1000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence Yes Immunogen Recombinant fragment corresponding to a region within amino acids 471 and 752 of alpha Dystroglycan (Uniprot ID#Q14118) Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Purified by antigen-affinity chromatography. Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Storage Instruction Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Tested Applications ICC/IF, WB Type Primary Western Blot Yes
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