40-511-产品快照
- 品牌:
- 40-511
- 型号:
- 40-511
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产品介绍
40-511
ProSci - 40-511 - GDNF Recombinant Protein, ProSci Inc (Each (2µG))
40-511
GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. Both the functional human and rat GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Store in working aliquots at -20°C. Avoid freeze/thaw cycles. This listing is for Each (2µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.002 mg Purity >98% Source E. coli Unit Each (2µG) Physical Form Lyophilized Species Human Murine Rat