AG40A0038C050-产品快照
- 品牌:
- AG40A0038C050
- 型号:
- AG40A0038C050
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产品介绍
AG40A0038C050
AdipoGen - AG40A0038C050 - IL-23 (human) (rec.) (Each (50µG))
AG40A0038C050
Interleukin-23 (IL-23) is a heterodimeric cytokine and a member of the IL-12 family involved in innate and adaptive immunity. It is composed of the IL-12 p40 chain covalently linked to p19, a chain related to the IL-12 p35 subunit. IL-23 signals through the IL-23 receptor complex, which is composed of the IL-12Rbeta1 chain and a gp130-like chain, IL-23R. Triggering of the IL-23 receptor complex leads to the activation of Tyk2, Jak2 and STAT1, 3 and 4. IL-23 induces IFN-gamma production, Th1 cell differentiation, and activation of the antigen-presenting functions of dendritic cells. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and important for tumorigenesis. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Host HEK 293 cells Form Liquid. Size 50 µg Unit Each (50µG) Biological Activity Induction of IL-17 secretion by mouse splenocytes. Clonality Protein Concentration 0.5mg/ml Long Term Storage -20°C Molecular Weight ~75kDa (SDS-PAGE) Purity >90% (SDS-PAGE) Sequence Human IL-23 p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the p19 peptide (aa 20-189) and fused at the N-terminus to a FLAG -tag. Short Term Storage +4°C Species Crossreactivity Human Stability Working aliquots are stable for up to 3 months when stored at -20°C. Storage Buffer 0.2µm-filtered solution in PBS.
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