79-437-产品快照
- 品牌:
- 79-437
- 型号:
- 79-437
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产品介绍
79-437
ProSci - 79-437 - MDM2 (Ab 166) Antibody, ProSci (Each (100µG))
79-437
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200 Antibodies were purified by affinity-chromatography using epitope-specific peptide. Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.1 mg Host Rabbit Species Reactivity Human, Mouse, Rat Tested Applications WB, IHC, IF Unit Each (100µG) Concentration 1 mg/mL Immunogen MDM2 (Ab-166) antibody was raised against a peptide sequence around aa.164~168 (A-I-S-E-T) derived from Human MDM2. Monoclonal/Polyclonal Polyclonal Physical Form Liquid Tested Applications WB, IHC, IF