10829-1-AP-产品快照
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- 10829-1-AP
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- 10829-1-AP
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产品介绍
10829-1-AP
Proteintech - 10829-1-AP - Rabbit Polyclonal Anti-HMGB1 Antibody, Proteintech Group (Each (150µl))
10829-1-AP
The HMG (high mobility group) proteins are nonhistone chromosomal proteins that is present in almost all eukaryotic cells, and it functions to stabilize NUCLEOSOME formation and acts as a transcription-factor-like protein that regulates the expression of several genes. Once injury, infection or other inflammatory stimuli, activated macrophages, mature dendritic cells and natural killer cells can secret HMGB1, which act as a crucial cytokine. HMGB1 also involved in V(D)J recombination by acting as a cofactor of the RAG complex, stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Act as a Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. HMGB1 (high mobility group box 1) modulates gene expression in the nucleus, but certain immune cells secrete HMGB1 as an extracellular Alarmin to signal tissue damage.The nuclear HMGB1 relocalizes to the extracellular milieu in senescent human and mouse cells in culture and in vivo, which stimulated cytokine secretion through TLR-4 signaling (23649808).This antibody is a rabbit polyclonal antibody raised against full length HMGB1 of human origin. This listing is for Each (150µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 150 µL Application WB:Jurkat Cells, 1:500-1:5000; IHC:Human breast cancer Tissue, 1:20-1:200; IP:HepG2 Cells, 1:200-1:2000 Tested Applications ELISA, WB, IHC, IP Unit Each (150µl) Antibody Isotype IgG Antibody Type Primary Antigen HMGB1 ChIP Yes Clonality Polyclonal ELISA Yes Flow Cytometry No Gel Shift No Host Rabbit ImmunoChemistry Yes ImmunoFluorescence No ImmunoPrecipitation Yes Immunogen Recombinant Protein Neutralisation No Purification Antigen affinity Purification Reactivity Human, Mouse, Rat Shipping Temperature Store at -20C Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Western Blot Yes
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