24235-1-AP-产品快照
- 品牌:
- 24235-1-AP
- 型号:
- 24235-1-AP
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产品介绍
24235-1-AP
Proteintech - 24235-1-AP - Rabbit Polyclonal Anti-TAF15 Antibody, Proteintech Group (Each (150µl))
24235-1-AP
TAF15 (TAF2N or TAFII68) is a nuclear protein known to associate with a distinct subpopulation of transcription factor IID (TFIID), a multi-subunit complex that nucleates the pre-initiation complex on promoters of on protein-coding genes. TAF15 harbors a transcriptional activation domain, a RNA recognition motif and many Arg-Gly-Gly repeats that participate in RNA binding. TAF15 along with FUS and EWS constitutes the FET (FUS/EWS/TAF15) protein family of heterogeneous nuclear ribonucleoproteins (hnRNPs) class of RNA binding proteins that are multifunctional proteins implicated in numerous aspects of RNA processing/functions. TAF15 is a nuclear protein that shuttle between cytoplasm-nucleus and as RNA/ssDNA-binding protein, it play specific roles during transcription initiation at distinct promoters and enter the preinitiation complex together with the RNA polymerase II. TAF15 as well as other FET member genes are frequently translocated in sarcomas and rare hematopoietic as well as epithelial cancers. Moreover, dominant mutations in genes coding for four hnRNPs (TDP-43, FUS/TLS, TAF15, and EWS) are found in familial and sporadic cases of ALS and a chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). This listing is for Each (150µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 150 µL Application WB:HEK-293 Cells, 1:500-1:5000; IHC:Human Testis, 1:20-1:200 Tested Applications ELISA, WB, IHC Unit Each (150µl) Antibody Isotype IgG Antibody Type Primary Antigen TAF15 ChIP No Clonality Polyclonal ELISA Yes Flow Cytometry No Gel Shift No Host Rabbit ImmunoChemistry Yes ImmunoFluorescence No ImmunoPrecipitation No Immunogen Fusion Protein Neutralisation No Purification Antigen Affinity Purified Reactivity Human Shipping Temperature Store at -20C Storage Buffer PBS with 0.0.2% sodium azide and 50% glycerol pH 7.3. Western Blot Yes