PM-4525-产品快照
- 品牌:
- PM-4525
- 型号:
- PM-4525
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产品介绍
PM-4525
ProSci - PM-4525 - PUMA Monoclonal Antibody, Prosci Inc (Each (100µG))
PM-4525
PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.1 mg Host Mouse Clone 2A9G5 Species Reactivity Human, Mouse, Rat Unit Each (100µG) Immunogen Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha. Monoclonal/Polyclonal Monoclonal Purification Immunoaffinity chromotography purified IgG Storage Buffer PBS containing 0.02% sodium azide Tested Applications E, WB
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