PM-4673-产品快照
- 品牌:
- PM-4673
- 型号:
- PM-4673
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产品介绍
PM-4673
ProSci - PM-4673 - MyD88 Monoclonal Antibody, Prosci Inc (Each (100µG))
PM-4673
MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.1 mg Host Mouse Clone 2E9C2 Species Reactivity Human, Mouse Unit Each (100µG) Immunogen Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88. Monoclonal/Polyclonal Monoclonal Purification Immunoaffinity chromotography purified IgG Storage Buffer PBS containing 0.02% sodium azide Tested Applications E, WB, IHC, IF
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