GTX11888-产品快照
- 品牌:
- GTX11888
- 型号:
- GTX11888
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产品介绍
GTX11888
Genetex - GTX11888 - MnSOD antibody - Goat Polyclonal (Each (50µG))
GTX11888
Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (Cu/Zn SOD) and manganese-containing SOD (Mn SOD). The Cu/Zn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from TNF-mediated apoptosis via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria. Mn SOD has also been shown to be a tumor suppressor in human breast cancer. Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen MNSOD Host Goat Reactivity Human, Mouse, Rat Isotype IgG Unit Each (50µG) Application Note WB: Use at a dilution of 1/1000 - 1/4000. Detects a band of approximately 24.7 kDa (predicted molecular weight: 26.6 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry No Immunofluorescence No Immunogen Immunogen was a synthetic peptide, which represented a portion of human manganese superoxide dismutase encoded within exon 3. Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Immunogen affinity purified Storage Buffer Preservative: 0.1% Sodium Azide; Constituents: Tris-citrate/phosphate. pH 7 - 8 Storage Instruction Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. Tested Applications WB Type Primary Western Blot Yes
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