15822-1-AP-产品快照
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- 15822-1-AP
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- 15822-1-AP
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产品介绍
15822-1-AP
Proteintech - 15822-1-AP - Rabbit Polyclonal Anti-PKM2-specific Antibody, Proteintech Group (Each (150µl))
15822-1-AP
PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2. PKM2, Pyruvate kinase isozymes M1/M2, has 2 isoforms .The immunogen of this antibody is M2 isoform, also called PKM2. This antibody is specific to PKM2 isoform. This listing is for Each (150µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 150 µL Application WB:MCF7 Cells, 1:500-1:5000; IHC:Human lung cancer Tissue, 1:20-1:200; IF:MCF-7 Cells, 1:10-1:100; IP:MCF-7 Cells, 1:200-1:1000 Tested Applications ELISA, WB, IHC, IF, IP Unit Each (150µl) Antibody Isotype IgG Antibody Type Primary Antigen PKM2-specific ChIP No Clonality Polyclonal ELISA Yes Flow Cytometry No Gel Shift No Host Rabbit ImmunoChemistry Yes ImmunoFluorescence Yes ImmunoPrecipitation Yes Immunogen Peptide Neutralisation No Purification Antigen affinity Purification Reactivity Human, Mouse Shipping Temperature Store at -20C Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Western Blot Yes
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