80-0032-U100-产品快照
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- 80-0032-U100
- 型号:
- 80-0032-U100
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产品介绍
80-0032-U100
Tonbo Biosciences - 80-0032-U100 - RedFluor 710 Anti-Mouse CD3 (17A2) (Each (100µG))
80-0032-U100
The 17A2 antibody reacts with the mouse CD3 complex, comprised of CD3 epsilon, CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. The 17A2 antibody is a widely used phenotypic marker for mouse T cells. In addition, as the CD3e chain within the TCR complex contains intracellular signaling domains, binding of 17A2 antibody to CD3 can induce cell activation (use format suitable for functional assays). A recent publication of the crystal structure of a murine CD3e-mitogenic antibody complex provides further insight into the action of commonly used agonist antibodies (Fernandes, R.A. et al. 2012. Journal of Biological Chemistry. 287: 13324-13335). This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science > Life Science > Cell Biology Size 100 μg Antigen CD3 Host Rat Reactivity Mouse Clone 17A2 Conjugate redFluor 710 Isotype IgG2b, k Unit Each (100µG) Storage Temperature Store Undiluted at 2 to 8°C; Protect from Light; Do Not Freeze. Synonyms CD3 epsilon Tested Applications Flow Cytometry
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