GTX61612-产品快照
- 品牌:
- GTX61612
- 型号:
- GTX61612
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产品介绍
GTX61612
Genetex - GTX61612 - N-Cadherin antibody [EPR1792Y], C-term (Each (100µl))
GTX61612
The cadherins are a large family of cell adhesion molecules involved in calcium-dependent recognition and adhesion events . Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are thought to be a regulator of such a process. Findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts . Human retinoblastoma and normal retinal tissue the type of cadherin, its relationship with cytoplasmic catenins, and its participation in invasion has been examined. Retinoblastoma cells, in contrast with normal retina, express an cadherin-2/catenin complex that is irregularly distributed and weakly linked to the cytoskeleton. In retinoblastoma, this complex acts as an invasion promoter . This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Installation Test & Maintenance > Test Equipment > Laboratory Supplies Antigen N-CADHERIN Host Rabbit Reactivity Human, Mouse, Rat Clone EPR1792Y Isotype IgG Molecular Weight 140 kDa Unit Each (100µl) Application Note Recommended Starting Dilutions: For WB: Use at a dilution of 1:10, 000-50, 000 For IHC: Use at a dilution of 1:500 -1000 For ICC: Use at a dilution of 1:100 - 250 For FACS: Use at a dilution of 1:30 For IP: Use at a dilution of 1:40 Optimal working dilution for a specific application should be determined by the investigator. ChIP No ELISA No Flow Cytometry Yes Gel Shift No Immunochemistry Yes Immunofluorescence Yes Immunogen A synthetic peptide corresponding to residues on the C-terminus of human Cadherin-2 was used as an immunogen. Immunoprecipitation Yes Monoclonal/Polyclonal Monoclonal Neutralization No Purification Cell Supernatant Storage Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Storage Instruction Store at -20 °C. Stable for 12 months from date of receipt. Tested Applications FACS, ICC/IF, IHC-P, IHC-M, IP, WB Type Primary Western Blot Yes
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