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- 20-1152-U100
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产品介绍
20-1152-U100
Tonbo Biosciences - 20-1152-U100 - APC Anti-Mouse CD115 (c-fms) (AFS98) (Each (100µG))
20-1152-U100
The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115. The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor (use format appropriate for functional assays). This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Installation Test & Maintenance > Test Equipment > Laboratory Supplies Size 100 μg Antigen CD115 (c-fms) Host Rat Reactivity Mouse Clone AFS98 Conjugate APC Isotype IgG2a, k Unit Each (100µG) Storage Conditions Store undiluted at 2-8°C, protect from light, do not freeze. Synonyms CSF-1-R, FMS, Colony-Stimulating Factor 1 Receptor, M-CSF Receptor, CSF1R Tested Applications Flow Cytometry
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