75-0086-T100-产品快照
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- 75-0086-T100
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- 75-0086-T100
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产品介绍
75-0086-T100
Tonbo Biosciences - 75-0086-T100 - VioletFluor 450 Anti-Human CD8a (OKT8) (Each (100µG))
75-0086-T100
The OKT8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites. The OKT8 antibody is widely used as a phenotypic marker for CD8 on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells. If used together with alternative antibodies Anti-Human CD8a clone RPA-T8 or Anti-Human CD8a clone Hit8a, the OKT8 antibody will not block binding of RPA-T8 or Hit8a. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Installation Test & Maintenance > Test Equipment > Laboratory Supplies Size 100 tests Antigen CD8a Host Mouse Reactivity Human Clone OKT8 Conjugate violetFluor 450 Isotype IgG2a Unit Each (100µG) Storage Temperature Store Undiluted at 2 to 8°C; Protect from Light; Do Not Freeze. Synonyms CD8 alpha, leu-2a Tested Applications Flow Cytometry
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