GTX105622-产品快照
- 品牌:
- GTX105622
- 型号:
- GTX105622
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产品介绍
GTX105622
Genetex - GTX105622 - MBD2 antibody [N2C3] (Each (100µl))
GTX105622
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. [provided by RefSeq] This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen MBD2 Host Rabbit Reactivity Human Isotype IgG Molecular Weight 43 kDa Unit Each (100µl) Application Note Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. ChIP ChIP - NO ELISA ELISA - NO Flow Cytometry Flow Cytometry - NO Gel Shift Gel Shift - NO ImmunoChemistry ImmunoChemistry - NO ImmunoFluorescence ImmunoFluorescense - NO ImmunoPrecipitation ImmunoPrecipitation - NO Immunogen Recombinant fragment corresponding to a region within amino acids 123 and 349 of MBD2 (Uniprot ID#Q9UBB5) Monoclonal/Polyclonal Polyclonal Neutralisation Neutralisation - NO Purification Purified by antigen-affinity chromatography. Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. Storage Instruction Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. Tested Applications WB Type Primary Western Blot Yes
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