GTX23697-产品快照
- 品牌:
- GTX23697
- 型号:
- GTX23697
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产品介绍
GTX23697
Genetex - GTX23697 - SOX9 antibody (Each (50µG))
GTX23697
SOX 9 is a member of the family of SOX (Sry-type high mobility group box) gene that were first identified on the basis of region with high homology to that of Sry (Sex determining region Y). It is a transcription factor with a high mobility group DNA-binding domain that is expressed in all prechondrocytic and chondrocytic cells during embryonic development in a pattern that close parallels that of the gene for type II collagen. Phosphorylation of SOX 9 by PKA increases its DNA binding and transcriptional activity. SOX 9 regulates expression of chondrocyte phenotype related genes. IL-1 and TNF-a can cause a marked and rapid decrease in the levels of SOX 9 mRNA and/or protein in chondrocytes, thus strongly inhibit the expression of genes for cartilage extracellular matrix proteins. The down-regulation of SOX 9 may have a crucial role in inhibiting expression of the cartilage phenotype in inflammatory joint diseases. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen SOX9 Host Rabbit Reactivity Chicken, frog, Human, Mouse, Rat Isotype IgG Unit Each (50µG) Application Note For Dot: Use at an assay dependent solution. For ELISA: Use at a concentration of 0.1 - 1.0 µg/ml. For IHC: Use at a concentration of 5-20 µg/ml. For WB: Use at a concentration of 0.5-2 µg/ml. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of approximately 61 kDa, which corresponds to the predicted molecular weight of SOX 9. ChIP No ELISA Yes Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence No Immunogen Synthetic peptide: KYQPRRRKSVKNG, corresponding to amino acids 173 - 185 of Human / Mouse / Bovine SOX 9. Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Immunogen affinity purified Storage Buffer PBS with 0.02% sodium azide Storage Instruction Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. Tested Applications Dot, ELISA, IHC, WB Type Primary Western Blot Yes
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