GTX29653-产品快照
- 品牌:
- GTX29653
- 型号:
- GTX29653
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产品介绍
GTX29653
Genetex - GTX29653 - BMF antibody (Each (100µG))
GTX29653
Apoptosis is related to many diseases and development. Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family. A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor) (1). The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton. Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program (1, 2). Bmf is constitutively expressed in many tissues (1, 2). This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen BMF Host Rabbit Reactivity Human Isotype IgG Unit Each (100µG) Application Note This antibody can be used for detection of Bmf by Western blot at 2 µg/ml. HepG2 or 293 cell lysate can be used as a positive control and a band at approximately 25 kDa can be detected. ChIP ChIP - NO ELISA ELISA - NO Flow Cytometry Flow Cytometry - NO Gel Shift Gel Shift - NO ImmunoChemistry ImmunoChemistry - NO ImmunoFluorescence ImmunoFluorescense - NO Immunogen Synthetic peptide: ALNGEENRNGAGPR, corresponding to amino acids 171-184 of Human Bmf. Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Immunogen affinity purified Storage Buffer PBS with 0.02% sodium azide Storage Instruction Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid freeze-thaw cycles. Tested Applications WB Type Primary Western Blot Yes
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