GTX48548-产品快照
- 品牌:
- GTX48548
- 型号:
- GTX48548
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产品介绍
GTX48548
Genetex - GTX48548 - Dnmt1 antibody [60B1220.1] (Each (50µG))
GTX48548
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Dnmt1 co-purifies with the retinoblastoma (Rb) tumour suppressor gene product, E2F1, and HDAC1. Dnmt1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites suggesting a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway that is disrupted in nearly all cancer cells. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen DNMT1 Host Mouse Reactivity Human, Mouse, zebrafish Clone 60B1220.1 Isotype IgG1, κ Unit Each (50µG) Application Note Recommended Starting Dilutions: For ChIP: Use at 1-2 µg/mL For IP: Use at 1-2 µg/mL For WB: Use at 2-4 µg/mL For IHC-P: Use at 1-2 ug/ml ChIP Yes ELISA No Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence No Immunogen This antibody was raised against a synthetic peptide corresponding to amino acids 637-650 (EKDDREDKENAFKR) of human Dnmt1 (Genbank Accession No. NP_001370). Immunoprecipitation Yes Monoclonal/Polyclonal Monoclonal Neutralization No Purification protein G purified Storage Buffer PBS containing 0.2% gelatin Storage Instruction Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. Tested Applications ChIP, IHC-P, IP, WB Type Primary Western Blot Yes
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