79-490-产品快照
- 品牌:
- 79-490
- 型号:
- 79-490
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产品介绍
79-490
ProSci - 79-490 - Integrin beta3 (phospho Tyr785) Antibody, ProSci (Each (100µG))
79-490
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Western Blot: 1:500~1:1000 Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.1 mg Host Rabbit Species Reactivity Human, Mouse Tested Applications WB Unit Each (100µG) Concentration 1 mg/mL Immunogen Integrin beta3 (Phospho-Tyr785) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 785 (I-T-Y (p) -R-G) derived from Human Integrin β3. Monoclonal/Polyclonal Polyclonal Physical Form Liquid Tested Applications WB
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