GTX12362-产品快照
- 品牌:
- GTX12362
- 型号:
- GTX12362
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产品介绍
GTX12362
Genetex - GTX12362 - Agrin antibody [AGR 131] (Each (100µG))
GTX12362
Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites; increasing the predicted MW from 200kDa to ~600kDa. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen AGRIN Host Mouse Reactivity Mouse, Rat Clone AGR 131 Isotype IgG1 Unit Each (100µG) Application Note ICC: Use at a dilution of 1/50 - 1/1000. IHC-Fr: Use at an assay dependent dilution. RIA: Use at a concentration of 1 μg/ml. WB: Use at a concentration of 2 μg/ml. Predicted molecular weight: 208.6 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence Yes Immunogen Recombinant rat agrin, C-terminal construct. Immunoprecipitation No Monoclonal/Polyclonal Monoclonal Neutralization No Purification Protein G purified Storage Buffer Preservative: NoneConstituents: 50% Glycerol, PBS, 0.1mM PMSF. pH 7.2 Storage Instruction Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. Tested Applications ICC/IF, IHC-Fr, RIA, WB Type Primary Western Blot Yes
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