GTX13699-产品快照
- 品牌:
- GTX13699
- 型号:
- GTX13699
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产品介绍
GTX13699
Genetex - GTX13699 - Lck antibody [33D196] (Each (100µG))
GTX13699
Lck is a lymphoid-specific cytosolic protein tyrosine kinase (PTK), which is essential for T-cell development and function. It is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated Lck to the vicinity of the TCR/CD3 complex. Lck then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAMs) in the cytoplasmic tails of the TCR-chains and CD3 subunits. The phospho-ITAMs serve as docking sites for Src homology domain 2 (SH2)-containing molecules, predominantly ZAP-70 and Syk. Only then can ZAP-70 undergo tyrosine phosphorylation, become enzymatically active and further phosphorylate downstream effector molecules. In addition, Lck contributes to signaling by other receptor molecules. Lck is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature TCR. This listing is for Each (100µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen LCK Host Mouse Reactivity Human, Mouse Clone 33D196 Isotype IgG2b Unit Each (100µG) Application Note WB: Use at a dilution of 1/500 - 1/1000. Detects a band of approximately 54 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry No Immunofluorescence No Immunogen Synthetic peptide (Human). Immunoprecipitation No Monoclonal/Polyclonal Monoclonal Neutralization No Purification Protein G purified Storage Buffer Preservative: 0.02% Sodium Azide; Constituents: PBS. Storage Instruction Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. Tested Applications WB Type Primary Western Blot Yes
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