GTX24841-产品快照
- 品牌:
- GTX24841
- 型号:
- GTX24841
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产品介绍
GTX24841
Genetex - GTX24841 - Tau (phospho Thr205) antibody (Each (50µl))
GTX24841
Tau is a neuronal microtubule-associated protein found predominantly on axons that functions to promote tubulin polymerisation and stabilise microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimeris disease (AD) brain. Hyperphosphorylated tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases including GSK 3 beta, protein kinase A (PKA), cyclin-dependent kinase 5 (Cdk 5) and casein kinase II, phosphorylate tau. Microtubule-dependent phosphorylation of threonine 205 is catalyzed by GSK 3 beta and Cdk 5 in vitro. This listing is for Each (50µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen TAU (Phospho THR205) Host Rabbit Reactivity Human, Mouse, Rat Isotype IgG Unit Each (50µl) Application Note For WB: Use at a dilution of 1:1000. Predicted molecular weight: 62 kDa. Can be blocked with GTX25239 Tau peptide - phospho T205 (phospho and non-phospho pair). Optimal dilutions/concentrations should be determined by the end user. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry No Immunofluorescence No Immunogen Synthetic peptide (Human) derived from the region of human tau that contains threonine 205. Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Affinity purified with antigen Storage Buffer Phosphate-buffered saline, pH 7.3 containing 1 mg/ml BSA, 50% glycerol and 0.05% sodium azide Storage Instruction Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. Tested Applications WB Type Primary Western Blot Yes
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