H-6216.0001-产品快照
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- H-6216.0001
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产品介绍
H-6216.0001
Bachem Americas - H-6216.0001 - Amyloid beta/A4 Protein Precursor770 (740-770), Bachem (Each (1mg))
H-6216.0001
Amyloid β/A4 Protein Precursor770 (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis. Sequence: H-Ala-Ala-Val-Thr-Pro-Glu-Glu-Arg-His-Leu-Ser-Lys-Met-Gln-Gln-Asn-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH Salt: Trifluoroacetate This listing is for Each (1mg) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 1 mg Unit Each (1mg) Salt Trifluoroacetate Synonyms C31, APP770 (740-770)
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