GTX62322-产品快照
- 品牌:
- GTX62322
- 型号:
- GTX62322
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产品介绍
GTX62322
Genetex - GTX62322 - Src antibody [EGTR103] (Each (100µl))
GTX62322
Src is a protein tyrosine kinase known to regulate cellular adhesion. Composed of three major domains; SH2, SH3 and a kinase catalytic domain, Src can be switched from an inactive to an active state though control of its phosphorylation state or through protein-protein interaction. Phosphorylation of Y529 by Csk and Chk inactivates Src, while dephosphorylation of Y529 will modify its conformation to an open active state . Mutation of Y529 leads to Scr overactivity. Several cancers including colon and breast cancer have been associated with an increase of Src activity . This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen SRC Host Rabbit Reactivity Human, Mouse, Rat Clone EGTR103 Isotype IgG Molecular Weight 60 kDa Unit Each (100µl) Application Note Recommended Starting Dilutions: For WB: Use at a dilution of 1:1, 000 - 10, 000 For IHC: Use at a dilution of 1:100 - 250. Optimal working dilution for a specific application should be determined by the investigator. ChIP No ELISA No Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence No Immunogen A synthetic peptide corresponding to residues to human Src was used as immunogen. Immunoprecipitation No Monoclonal/Polyclonal Monoclonal Neutralization No Purification Cell Supernatant Storage Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Storage Instruction Store at -20 °C. Stable for 12 months from date of receipt. Tested Applications IHC-P, IHC-M, WB Type Primary Western Blot Yes