GTX20201-产品快照
- 品牌:
- GTX20201
- 型号:
- GTX20201
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产品介绍
GTX20201
Genetex - GTX20201 - ErbB2 (phospho Thr686) antibody (Each (100µl))
GTX20201
ErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1&2 and JAK/STAT signaling pathways, respectively. This listing is for Each (100µl) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Antigen ERBB2 (Phospho THR686) Host Rabbit Reactivity Human Isotype IgG Unit Each (100µl) Application Note For ELISA: Use at an assay dependent dilution. For IHC-Fr: Use at a dilution of 1:500. For WB: Use at a dilution of 1:1, 000-1:5, 000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. ChIP No ELISA Yes Flow Cytometry No Gel Shift No Immunochemistry Yes Immunofluorescence No Immunogen Threonine phosphorylated peptide KIRKY T MRRLL from c-erbB-2 sequence Immunoprecipitation No Monoclonal/Polyclonal Polyclonal Neutralization No Purification Unpurified Storage Buffer Contains 0.09% sodium azide Storage Instruction Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. Tested Applications ELISA, IHC-Fr, WB Type Primary Western Blot Yes
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