49-164-产品快照
- 品牌:
- 49-164
- 型号:
- 49-164
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产品介绍
49-164
ProSci - 49-164 - GRM1 Antibody, ProSci (Each (50µG))
49-164
The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 2.5 μg/mL, and immunoprecipitation Immunoaffinity Chromatography PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide. Aliquot and store at 4ºC. Avoid freezing. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.05 mg Host Rabbit Species Reactivity Human, Mouse, Rat Tested Applications WB, IHC, IP Unit Each (50µG) Immunogen GRM1 antibody was raised against a synthetic peptide near the C-Terminus of GRM1 (Human). Monoclonal/Polyclonal Polyclonal Physical Form Liquid Tested Applications WB, IHC, IP
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