49-655-产品快照
- 品牌:
- 49-655
- 型号:
- 49-655
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产品介绍
49-655
ProSci - 49-655 - ARNT Antibody, ProSci (Each (50µG))
49-655
Transcriptional responses to many environmental and developmental stimuli are mediated by the basic helix-loop-helix (bHLH)-PAS family of proteins, which form homodimers that bind regulatory DNA sequences. ARNT/HIF-1 beta regulates the expression of different sets of genes in response to distinct environmental challenges. ARNT forms a complex with arylhydrocarbon receptor (AHR) to activate expression of genes encoding P450. Once AHR binds it ligand, it associates with ARNT for transport into the nucleus. ARNT also dimerizes with HIF-1alpha, -2 alpha or -3 alpha in response to low oxygen concentration to induce the expression of hypoxia-regulated genes encoding vascular endothelial growth and other genes. The expression of ARNT/HIF-1beta remains fairly constant and the protein is found in the nucleus and the cytoplasm. ARNT antibody can be used in ELISA starting at 1:20000 - 1:100000, Western Blot starting at 1:500 - 1:5000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence. Protein G Column PBS, 0.1% sodium azide. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. This listing is for Each (50µG) See other products in some related categories (click to browse): Industrial & Scientific > Laboratory & Science Size 0.05 mg Host Rabbit Species Reactivity Human Tested Applications E, IHC Unit Each (50µG) Immunogen Amino acids 528 to 544 of human ARNT Monoclonal/Polyclonal Polyclonal Physical Form Liquid Tested Applications E, IHC