18164-1-AP-产品快照
- 品牌:
- 18164-1-AP
- 型号:
- 18164-1-AP
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产品介绍
18164-1-AP
Proteintech - 18164-1-AP - Rabbit Polyclonal Anti-PMS2 Antibody, Proteintech Group (Each (150µl))
18164-1-AP
PMS2, also named as PMSL2, belongs to the DNA mismatch repair mutL/hexB family. It is a component of the post-replicative DNA mismatch repair system (MMR). It heterodimerizes with MLH1 to form MutL alpha. MulL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. It also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4). Defects in PMS2 are a cause of mismatch repair cancer syndrome (MMRCS). This antibody is special to PMS2. This listing is for Each (150µl) See other products in some related categories (click to browse): Industrial & Scientific > MRO Products & Supplies Size 150 µL Application WB:A431 Cells, 1:200-1:2000 Tested Applications ELISA, WB Unit Each (150µl) Antibody Isotype IgG Antibody Type Primary Antigen PMS2 ChIP No Clonality Polyclonal ELISA Yes Flow Cytometry No Gel Shift No Host Rabbit ImmunoChemistry No ImmunoFluorescence No ImmunoPrecipitation No Immunogen Recombinant Protein Neutralisation No Purification Antigen affinity Purification Reactivity human, Mouse, Rat Shipping Temperature Store at -20C Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Western Blot Yes